treatment of disc degenerative disease using stem cells in mice. We discuss a paper by Fan Yang et al. in the journal Molecular Therapy entitled “Mesenchymal Stem Cells Arrest Intervertebral Disc Degeneration Through Chondrocytic Differentiation and Stimulation of Endogenous Stem Cells
#1 by arfx3 on November 10th, 2011
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Im interested in seeking this treatment. I have a question, however. If a disc or multiple discs are degenerated and therefore shorter in height…would stem cells not only heal the disc but also increase the height of the disc……therefore increasin the height of the patient ( im guessing by 2-3 cm for mutliple discs)??
#2 by cellmedicine on November 10th, 2011
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just dont add platelet rich plasma WITH stem cells in the nucleus pulposus because there is at least one paper suggesting that instead of chondrocytes you get bone
#3 by ameeek on November 10th, 2011
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there are many pros and cons to stem cell therapy, you may try to look just at something like platelet rich plasma, it seems a lot easier than putting in whole stem cells
#4 by cellmedicine on November 10th, 2011
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good call…may need to through it some MMP inhibitor or some TIMPs to get a bigger effect !
#5 by jonlamarre on November 10th, 2011
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the stem cells may express a lot of matrix metalloproteases that could actually accelerate the process of nucleus pulposus degradation, no?
#6 by drfabianlara on November 10th, 2011
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Great presentation Tom!!!
#7 by floricabatu on November 10th, 2011
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i wonder biological significance of having nucleus pulposus immunologically inert?
#8 by stemcellscientist on November 10th, 2011
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this is compelling evidence that the simply process of injecting stem cells into the back can have some pretty profound effects. This may be one of te easiest to treat conditions since the nucleus pulposus is full of functional fas ligand…so this means that you dont need to inject cells from the same donor bu tyou can use allogeneic cells as universal stem cell donors. while in the paper they talk about mesenchymal stem cells, ii dont see anything wrong with expanding autologous NP cells
#9 by skatergirl333 on November 10th, 2011
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exceptional tom
#10 by insightertrading on November 10th, 2011
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Another great video Tom! I get excited every time I see a mesenchymal repair something new. Keep it up! Rick.
#11 by emirapper on November 10th, 2011
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interesting that stem cells can also be used for this condition